1
My lab is looking for a project manager. If you are interested in a research associate position to oversee biorepository and manage cool #longCOVID immune profiling and #neuroimmune mouse projects, please apply below 👇🏽
sjobs.brassring.com/TGnewUI/Search…
2
Today, we enrolled our 100th long covid patients in our collaboration with the @PutrinoLab to understand the pathogenesis of #longCOVID. So grateful to David, his team members and the patients for donating their blood samples 🙏🏼
3
Overall, this study adds to growing evidence that vaccines can improve symptoms and lessen the disease impact in #longCOVID.
What is the evidence? An important patient survey from @LongCovidSOS showed impact of vaccines on long covid symptoms. (5/)
…e-4609-b25f-6f3d1497c4cf.filesusr.com/ugd/8bd4fe_a33…
4
I am thrilled to give a talk on “Probing disease mechanisms of long COVID” today. I will highlight many other post acute infection syndromes that lead to ME CFS, and present hypotheses and clues on the pathogenesis of #longCOVID.
deloitte.zoom.us/webinar/regist…
5
Very interesting. Vaccines can induce immune responses to clear persistent viral infection. Relevance to #longCOVID?
In this WAS patient;
1) mRNA vax (but not infection) induced antibody to the Spike
2) mRNA vax ⬆️ IFN-g secreting T cells
3) Vax cleared persistent 🦠 twitter.com/Primary_Immune…
6
A preprint by Michael Simon et al @ArcadiaHealthIT shows that COVID vaccines given before or AFTER infection can reduce incidence of #longCOVID, based on a retrospective analysis of the health record of 240,648 COVID-19-infected people. 🧵(1/)
medrxiv.org/content/10.110…
7
In #longCOVID patients, “exercise capacity was primarily limited by impaired systemic EO2 of such severity that what should have been an adequate increase in DO2 was insufficient to allow for an increase in VO2.” Via @YalePCCSM
sciencedirect.com/science/articl…
8
So the problem in #longCOVID is not necessarily O2 supply (thus normal cardiopulmonary function) but O2 extraction and thus consumption by tissue. What could cause such defects? Microvascular abnormality? I would love expert input here. @KaminskiMed, @CharleszYaleMed?
9
Has anyone else with #longCOVID received monoclonal antibodies to SARS-CoV-2? Please share your experience. More data will help justify a clinical trial. Thank you. twitter.com/AlisaValdesRod…
10
Nasal Spray Booster Keeps COVID-19 at Bay - an excellent piece by Meghan Rosen.
So grateful to @HHMINEWS for stepping up and supporting our research efforts on COVID - on acute COVID, #longCOVID pathogenesis and vaccine strategies against SARS-CoV-2 🙏🏼
hhmi.org/news/nasal-spr…
11
Check out our latest review on the immunology and immunopathology of COVID-19 (both acute and #longCOVID). So fortunate to work with brilliant #womeninSTEM on this review - my #shero friends @MiriamMerad @blish_lab @sallustolab 💪🏼
science.org/doi/10.1126/sc…
12
Thank you @ASlavitt for speaking up about #longCOVID 🙏🏼 We need a lot more public attention, research, therapy and drugs to combat this debilitating disease. We also need similar attention/resources/research/treatment for #MECFS that results after infection with other pathogens. twitter.com/ASlavitt/statu…
13
With millions of #longCOVID patients, it is becoming better known that even a mild infection can lead to longterm debilitating health problems. SARS-CoV-2 joins the long list of other pathogens that cause post-acute infection syndrome (PAIS). (2/)
14
What could be the possible causes of PAIS? Similar to #longCOVID, we hypothesize a) pathogen reservoir/remnants, b) autoimmunity, c) dysbiosis of microbiome/virome, and d) unrepaired tissue damage. None are mutually exclusive. (6/)
15
An important study by @zalaly and colleagues of >13 million people shows that vaccines (prior to infection) only reduce #longCOVID risk by 15% with the largest risk reduction in blood clots and pulmonary sequelae but less protection of other organ systems. Please wear a mask! twitter.com/zalaly/status/…
16
Reflection: persistent viral RNA has been seen post-COVID and after other viral infections. Targeting and getting rid of such RNA may hold key to the treatment of #longCOVID and #MECFS patients who suffer from this pathogenesis. (End)
17
当院で翻訳したWHO欧州地域事務局作成の「リハビリテーションの支援：COVID-19関連疾患後の自己管理 第2版」Suppot for rehabilitation: Self-management after COVID-19-related illnessを修正しました #コロナ後遺症 #longCOVID 第2版の翻訳版の第2版です(笑)
drive.google.com/file/d/1ZaJxNJ…
18
I am honored to be included in this video to discuss #longCOVID. So grateful to the patients including @pamelarbishop @EfCovid19 @loscharlos for speaking up and teaching us what living with COVID is like. Please watch this today. @KnowableMag
youtube.com/watch?v=7lfGu_…
19
Here is the summary of our findings. There are many implications for diagnosis and therapy for #longCOVID. (26/)
20
I could not agree more with @EricTopol 👇🏽
While we are gaining more insights into the disease pathogenesis of #longCOVID, we also need to start well-designed randomized clinical trials now! Patients cannot wait any longer, and scientists will learn from RCTs to improve therapy. twitter.com/EricTopol/stat…
21
新型コロナ後遺症に関する私たちの研究についてお話しを記事にしていただきました。メカニズムの解析は進んでいますが、さらなる研究と臨床試験が必要です。世界中で苦しんでいる多くの人に役立つ治療に貢献したいです。是非日経サイエンスの特集を読んで下さい👇🏽 #longCOVID
nikkei-science.com/202211_039.html
22
Grateful for the opportunity to coauthor this review with the incredible @michelle_monje 🙏🏼 We discuss pathobiology of #longCOVID in the central nervous system and speculate on chief mechanisms that contribute to this emerging neurological health crisis.
cell.com/neuron/fulltex…
23
For those who are interested in learning more about how COVID and #longCOVID can impact the brain, I highly recommend this video interview by @KnowableMag of @michelle_monje 👇🏽
knowablemagazine.org/article/health…
24
A more general discussion and powerful testimony by #longCOVID patients can be found in this video by @KnowableMag. I share hypotheses on disease pathogenesis and discuss possible therapies. Please listen to the patients and learn more.
knowablemagazine.org/article/health…
25
Is there anything we can do to prevent long COVID, once we catch the virus? Research by @zalaly and colleagues shows that Paxlovid treatment within 5 days of a positive test led to 26% less risk of #longCOVID, regardless of vaccine status. (1/2)
medrxiv.org/content/10.110…