1
We are now enrolling in the #PaxLCTrial; randomizing people with #longCOVID to 15 days of Paxlovid (nirmatrelvir/ritonavir) or placebo (placebo/ritonavir). Currently people in CT, NY, and FL can enroll. Hope to expand to other states soon. For more info 👉🏼 kindred.hugo.health/pax-lc
2
We suspect that a subset of #longCOVID patients have viral reservoirs. The reason we use a 15-day trx (not a 5-day used for acute infection) is to allow the drug to eliminate the virus that is causing chronic infection and to remove such reservoirs. (4/)
nature.com/articles/s4159…
3
Very excited that our PaxLC clinical trial on #longCOVID patients is now open, led by @hmkyale! This is a phase 2, 1:1 randomized, double-blind, placebo-controlled research study in 100 non-hospitalized highly symptomatic long COVID. (1/)
clinicaltrials.gov/ct2/show/NCT05…
4
A team member working on our #PrimeandSpike nasal spray COVID booster vaccine developed #longCOVID 😭
Long COVID is a global crisis affecting millions of lives. It is impacting our ability to do science, research and development.
5
We are looking for people who never had COVID or who recovered from COVID as important control participants in our Yale LISTEN study. Please sign up if you can help us understand the pathophysiology of #longCOVID and post-vaccine adverse events 🙏🏼
medicine.yale.edu/ycci/listen-st…
6
A very important and informative thread about why the Omicron XBB.1.5 subvariant is now dominating in the Northeast US and is expected to spread. Please protect yourselves and others by wearing N95 masks. I am truly concerned about the #longCOVID wave that follows this infection. twitter.com/yunlong_cao/st…
7
@cstroeckw Many thanks to you and other patient advocates, this pandemic has propelled me to investigate the pathobiology of #longCOVID, #MECFS and #longLyme 🙏🏼 If enough people do the same, we can change how society and medicine view post-acute infection syndromes.
8
Delighted to host @resiapretorius and @PutrinoLab at Yale today. @ValterVSM and I learned how to image #microclots and activated platelets. Activated platelet stained with anti-CD62P antibody are evident just looking through the eyepiece 👀 This is from a #longCOVID patient👇🏽😭
9
Is there anything we can do to prevent long COVID, once we catch the virus? Research by @zalaly and colleagues shows that Paxlovid treatment within 5 days of a positive test led to 26% less risk of #longCOVID, regardless of vaccine status. (1/2)
medrxiv.org/content/10.110…
10
A more general discussion and powerful testimony by #longCOVID patients can be found in this video by @KnowableMag. I share hypotheses on disease pathogenesis and discuss possible therapies. Please listen to the patients and learn more.
knowablemagazine.org/article/health…
11
For those who are interested in learning more about how COVID and #longCOVID can impact the brain, I highly recommend this video interview by @KnowableMag of @michelle_monje 👇🏽
knowablemagazine.org/article/health…
12
Grateful for the opportunity to coauthor this review with the incredible @michelle_monje 🙏🏼 We discuss pathobiology of #longCOVID in the central nervous system and speculate on chief mechanisms that contribute to this emerging neurological health crisis.
cell.com/neuron/fulltex…
13
新型コロナ後遺症に関する私たちの研究についてお話しを記事にしていただきました。メカニズムの解析は進んでいますが、さらなる研究と臨床試験が必要です。世界中で苦しんでいる多くの人に役立つ治療に貢献したいです。是非日経サイエンスの特集を読んで下さい👇🏽 #longCOVID
nikkei-science.com/202211_039.html
14
I could not agree more with @EricTopol 👇🏽
While we are gaining more insights into the disease pathogenesis of #longCOVID, we also need to start well-designed randomized clinical trials now! Patients cannot wait any longer, and scientists will learn from RCTs to improve therapy. twitter.com/EricTopol/stat…
15
Here is the summary of our findings. There are many implications for diagnosis and therapy for #longCOVID. (26/)
16
I am honored to be included in this video to discuss #longCOVID. So grateful to the patients including @pamelarbishop @EfCovid19 @loscharlos for speaking up and teaching us what living with COVID is like. Please watch this today. @KnowableMag
youtube.com/watch?v=7lfGu_…
17
当院で翻訳したWHO欧州地域事務局作成の「リハビリテーションの支援：COVID-19関連疾患後の自己管理 第2版」Suppot for rehabilitation: Self-management after COVID-19-related illnessを修正しました #コロナ後遺症 #longCOVID 第2版の翻訳版の第2版です(笑)
drive.google.com/file/d/1ZaJxNJ…
18
Reflection: persistent viral RNA has been seen post-COVID and after other viral infections. Targeting and getting rid of such RNA may hold key to the treatment of #longCOVID and #MECFS patients who suffer from this pathogenesis. (End)
19
An important study by @zalaly and colleagues of >13 million people shows that vaccines (prior to infection) only reduce #longCOVID risk by 15% with the largest risk reduction in blood clots and pulmonary sequelae but less protection of other organ systems. Please wear a mask! twitter.com/zalaly/status/…
20
What could be the possible causes of PAIS? Similar to #longCOVID, we hypothesize a) pathogen reservoir/remnants, b) autoimmunity, c) dysbiosis of microbiome/virome, and d) unrepaired tissue damage. None are mutually exclusive. (6/)
21
With millions of #longCOVID patients, it is becoming better known that even a mild infection can lead to longterm debilitating health problems. SARS-CoV-2 joins the long list of other pathogens that cause post-acute infection syndrome (PAIS). (2/)
22
Thank you @ASlavitt for speaking up about #longCOVID 🙏🏼 We need a lot more public attention, research, therapy and drugs to combat this debilitating disease. We also need similar attention/resources/research/treatment for #MECFS that results after infection with other pathogens. twitter.com/ASlavitt/statu…
23
Check out our latest review on the immunology and immunopathology of COVID-19 (both acute and #longCOVID). So fortunate to work with brilliant #womeninSTEM on this review - my #shero friends @MiriamMerad @blish_lab @sallustolab 💪🏼
science.org/doi/10.1126/sc…
24
Nasal Spray Booster Keeps COVID-19 at Bay - an excellent piece by Meghan Rosen.
So grateful to @HHMINEWS for stepping up and supporting our research efforts on COVID - on acute COVID, #longCOVID pathogenesis and vaccine strategies against SARS-CoV-2 🙏🏼
hhmi.org/news/nasal-spr…
25
Has anyone else with #longCOVID received monoclonal antibodies to SARS-CoV-2? Please share your experience. More data will help justify a clinical trial. Thank you. twitter.com/AlisaValdesRod…