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So the problem in #longCOVID is not necessarily O2 supply (thus normal cardiopulmonary function) but O2 extraction and thus consumption by tissue. What could cause such defects? Microvascular abnormality? I would love expert input here. @KaminskiMed, @CharleszYaleMed?
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In #longCOVID patients, “exercise capacity was primarily limited by impaired systemic EO2 of such severity that what should have been an adequate increase in DO2 was insufficient to allow for an increase in VO2.” Via @YalePCCSM
sciencedirect.com/science/articl…
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A preprint by Michael Simon et al @ArcadiaHealthIT shows that COVID vaccines given before or AFTER infection can reduce incidence of #longCOVID, based on a retrospective analysis of the health record of 240,648 COVID-19-infected people. 🧵(1/)
medrxiv.org/content/10.110…
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Very interesting. Vaccines can induce immune responses to clear persistent viral infection. Relevance to #longCOVID?
In this WAS patient;
1) mRNA vax (but not infection) induced antibody to the Spike
2) mRNA vax ⬆️ IFN-g secreting T cells
3) Vax cleared persistent 🦠 twitter.com/Primary_Immune…
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I am thrilled to give a talk on “Probing disease mechanisms of long COVID” today. I will highlight many other post acute infection syndromes that lead to ME CFS, and present hypotheses and clues on the pathogenesis of #longCOVID.
deloitte.zoom.us/webinar/regist…
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Overall, this study adds to growing evidence that vaccines can improve symptoms and lessen the disease impact in #longCOVID.
What is the evidence? An important patient survey from @LongCovidSOS showed impact of vaccines on long covid symptoms. (5/)
…e-4609-b25f-6f3d1497c4cf.filesusr.com/ugd/8bd4fe_a33…
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Today, we enrolled our 100th long covid patients in our collaboration with the @PutrinoLab to understand the pathogenesis of #longCOVID. So grateful to David, his team members and the patients for donating their blood samples 🙏🏼
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My lab is looking for a project manager. If you are interested in a research associate position to oversee biorepository and manage cool #longCOVID immune profiling and #neuroimmune mouse projects, please apply below 👇🏽
sjobs.brassring.com/TGnewUI/Search…