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We are now enrolling in the #PaxLCTrial; randomizing people with #longCOVID to 15 days of Paxlovid (nirmatrelvir/ritonavir) or placebo (placebo/ritonavir). Currently people in CT, NY, and FL can enroll. Hope to expand to other states soon. For more info 👉🏼 kindred.hugo.health/pax-lc
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@bucketwoman0 @DocMoschos @kallmemeg Yes. Fully vaccinated people can still get long covid. Please see this entire thread by @dianaberrent 👇🏽 twitter.com/dianaberrent/s…
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What immune cell features are most predictive of COVID outcomes?
@mkuchroo @JcsHuang Patrick Wong et al used ML algorithm Multiscale PHATE to assign each immune cell type in COVID patients a mortality-likelihood score. Latest from @KrishnaswamyLab 💪🏼 (1/)
go.nature.com/3K0QCqi
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What does a respiratory-only mild COVID do to the brain? @ThisIsAnthonyFC and @AnnaGeraghty2 examined the subcortical white matter of two independent strains of mice and found consistently increased microglial reactivity at 7 days and 7 weeks post infection. (7/)
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A more general discussion and powerful testimony by #longCOVID patients can be found in this video by @KnowableMag. I share hypotheses on disease pathogenesis and discuss possible therapies. Please listen to the patients and learn more.
knowablemagazine.org/article/health…
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Q: Why can nasal vaccines do?
A:“Nasal sprays assemble a separate set of antibodies known as immunoglobulin A (IgA). These populate the spongy mucosal tissues of the nose, mouth and throat, where the COVID-causing coronavirus first lands." #PrimeandSpike
By @mvbroadfoot twitter.com/sciam/status/1…
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@dianaberrent @DanielGriffinMD I think this is possible, @dianaberrent. A higher viral load exposure will give more opportunity for the virus to replicate robustly in the olfactory mucosa and invade the CNS, after crossing the cribriform plate. This needs to be tested for Delta.
nature.com/articles/s4159…
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@mocoband @fitterhappierAJ @DrEricDing @EricTopol @DrPatSoonShiong @farid__jalali @dgurdasani1 @jeremyfaust @ToshiAkima @RadCentrism @LeonardiBot @EnemyInAState Thank you @mocoband for sharing. This report adds to a growing evidence of viral persistence in the GI tract, possibly aided by virus shutting down MHC I and evading T cell killing.
biorxiv.org/content/10.110…
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What does this mean? Immune evasion from CD8 T cells could allow infected cells to survive better in the host. The virus could establish a safe niche for prolonged replication. To eliminate such persistent reservoirs, we need to employ antivirals or antibody therapy. (4/)
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These results indicate that nasal vaccines induce IgA and promote better cross-protective immunity against viral variants, and suggest its utility in combating COVID-19 variants of concern. A great write up by Bill Hathaway. (13/)
news.yale.edu/2021/12/10/nas…
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In conclusion, VOCs do not evolve to further escape from CD8 T beyond the ancestral SARS-CoV-2 virus. The virus uses multiple pathways to inhibit MHC I. If one is missing, others compensate. Given this, CD8 T cell-based therapeutic approaches may be difficult for COVID-19. (End)
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So truly honored to be named a @Yale Sterling Professor 🙏🏼
medicine.yale.edu/news-article/i…
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This is so interesting, giving the report by @SuYapeng et al showing similar reduction in long haulers with respiratory viral symptoms at 2-3 months post COVID. This implies chronic hypocortisolism in long COVID. (14/)
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New data are pretty striking. Compared to the ancestral (WA1) or Epsilon (B.1.429) variant, Omicron subvariants BA.1, BA.2.12.1, XAF and BA.4 all suppressed MHC I surface expression better in infected cells. An irrelevant surface marker (CD324) was not affected by infection. (4/)
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Cortisol levels in circulation were about half of the control groups. Despite this, we saw no elevation in ACTH levels, suggesting an impaired compensatory response by the hypothalamic-pituitary axis. (13/)
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I am thrilled to give a talk on “Probing disease mechanisms of long COVID” today. I will highlight many other post acute infection syndromes that lead to ME CFS, and present hypotheses and clues on the pathogenesis of #longCOVID.
deloitte.zoom.us/webinar/regist…
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Long COVID participants reported a number of symptoms, most commonly fatigue, brain fog, dysautonomia..etc. Hierarchical clustering of binary symptom data identified 3 clusters of patients with similar sets of self-reported symptoms. (6/)
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We suspect that a subset of #longCOVID patients have viral reservoirs. The reason we use a 15-day trx (not a 5-day used for acute infection) is to allow the drug to eliminate the virus that is causing chronic infection and to remove such reservoirs. (4/)
nature.com/articles/s4159…
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So excited to launch the new Center for Infection & Immunity @YaleCII at @YaleMed!! This center will investigate fundamental mechanisms of infection and immunity that hold key to better prevention, diagnosis and treatment of wide range of diseases. (1/)
medicine.yale.edu/cii/
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This again is consistent with the report by @SuYapeng et al, showing that EBV viremia at the time of diagnosis is one of the four predictive factors for long COVID. (Note that our study did not examine viremia but infer EBV reactivation by serology)(19/)
sciencedirect.com/science/articl…
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We measured antibody levels against SARS-CoV-2 antigens in people who received 2 doses of mRNA vaccines. Curiously, long COVID patients produced higher levels of IgG against Spike. Without vaccines, LC had higher IgG against nucleocapsid. Data suggest persistent antigen? (10/)
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In this new Neuroview in @NeuroCellPress, I discuss "How COVID-19 has transformed my science”. Recounting my personal journey of how I responded to the pandemic, and how the pandemic has transformed the way I do science. Some lessons learned. (1/n)
cell.com/neuron/fulltex…
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Such an honor to discuss with Prof. Ron Davis of @StanfordMed about #MECFS - metabolism, chemistry, viruses and immunology!
Start of a great collaboration.
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I’m so grateful that @japanairlinesJP requires masking in the airplane and at airports 🙏🏼
Taking off to Tokyo to celebrate the winners of the Maria Sklodowska-Curie Prize for young female scientists 👩🏻🔬
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Every school bus in the country should be adhering to these guidelines to avoid COVID transmission.
✅ Universal masking
✅ SalivaDirect testing
✅ <2 students/seat with the exception of 3/seat with siblings
✅ a one-inch window opening in the 2 middle and 2 last row windows twitter.com/linseymarr/sta…
We study innate and adaptive immunity against viruses and study disease pathogenesis. #COVID19 #longCOVID #vaccines @HHMINEWS @YaleIBIO @YaleMed @YaleCII