1
やっと完成しました。日本の皆様のために、mR N Aワクチンの有効性と安全性についてのビデオを作ってみました。お役に立てると嬉しいです。１日も早く、ワクチンを打って集団免疫を獲得しましょう！リツイートお願いします。
youtu.be/uv9lVaxA8NY
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A very important and informative thread about why the Omicron XBB.1.5 subvariant is now dominating in the Northeast US and is expected to spread. Please protect yourselves and others by wearing N95 masks. I am truly concerned about the #longCOVID wave that follows this infection. twitter.com/yunlong_cao/st…
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Very excited to share our latest research on immunological features of #LongCovid. Our 2+ year collaboration with @PutrinoLab with many other fantastic colleagues and patients - Mount Sinai Yale Long COVID (MY-LC) study by @sneakyvirus1 et al. 🧵(1/)
medrxiv.org/content/10.110…
4
So excited to be a part of this important study led by @michelle_monje on how significant longterm neurologic damage can occur after a mild respiratory-only SARS-CoV-2 infection. My own🧵on the findings of this study with relevance to #longCovid (1/)
biorxiv.org/content/10.110…
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Here is the summary of our findings. There are many implications for diagnosis and therapy for #longCOVID. (26/)
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Vaccines that reduce infection & disease are needed to combat the pandemic. Here, @tianyangmao @BenIsraelow et al. describe our new mucosal booster strategy, Prime and Spike, to induce such immunity via nasal delivery of unadjuvanted spike vaccine 🧵 (1/)
biorxiv.org/content/10.110…
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Breakthrough infections are uncommon. However, you can get #longcovid from breakthrough infection. We don’t know how frequently long covid develops in fully vax people because CDC is not collecting such data. It is dangerous to get breakthrough infections. Please #vaxandmask
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It’s time to invest in next generation COVID vaccines that not only prevent severe disease but also block infection and transmission. It makes sense to induce mucosal immunity to fight a mucosal viral infection. My opinion in @nytimes today👇🏽
nytimes.com/2022/05/16/opi…
9
How can a mild respiratory SARS-CoV-2 infection lead to longterm neurological symptoms? Possibilities include 1) direct infection of 🧠, 2) autoimmunity, and 3) inflammatory impact of infection distal to the 🧠. In this study, we focused on 3) 👇🏽 (2/)
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We need your help for some crucial #LongCOVID research! If you live in the New York area, have FULLY recovered from COVID-19 infection and it has been AT LEAST 12 weeks since you were first sick, please email us at prcovid@mountsinai.org @PutrinoLab
RT highly appreciated 🙏🏼
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An excellent article by @patrickc highlighting the barriers for academics like myself to develop universal and nasal COVID vaccines. We need government to empower someone to intervene and lift the roadblocks. Funding alone is not enough. Please read & RT👇🏽
slowboring.com/p/we-could-hav…
12
Very happy to see that China approved the world’s first inhaled vaccine against COVID-19. Convidecia Air is an aerosolized vaccine based on Ad5-nCoV made by Cansino.
fortune.com/2022/09/05/can…
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In a nutshell, this study illustrates that respiratory-only mild SARS-CoV-2 infection can lead to detrimental changes in the brain, likely mediated by inflammatory factors. Similar neuropathobiology may be shared in chemo-brain, post-ICU syndrome and ME/CFS. (15/)
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CoronaVac is an inactivated SARS-CoV-2 vaccine approved for use in 48 countries. In collaboration with the Ministry of Health in Dominican Republic, we tested whether CoronaVac (2x) + Pfizer booster induces neutralizing Abs to Delta and Omicron. (1/)
medrxiv.org/content/10.110…
15
Delighted to host @resiapretorius and @PutrinoLab at Yale today. @ValterVSM and I learned how to image #microclots and activated platelets. Activated platelet stained with anti-CD62P antibody are evident just looking through the eyepiece 👀 This is from a #longCOVID patient👇🏽😭
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Amazing, timely, comprehensive, and evidence-based review - Long COVID: major findings, mechanisms and recommendations - by @ahandvanish @LisaAMcCorkell @juliamv @EricTopol. This is a #MustRead and is already my go-to review on #LongCovid.
nature.com/articles/s4157…
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In terms of public health, CoronaVac 2x is insufficient to neutralize Omicron. Even with CoronaVac 2x plus Pfizer booster, NAb is only 1.4x higher than 2x mRNA alone. Thus, CoronaVac recipients may need 2 additional booster doses to reach levels needed against Omicron. (10/)
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A brilliant & timely review by Prof. #DianeEGriffin on the persistence of viral RNA following RNA virus infection - which can be associated with late progressive disease or nonspecific lingering symptoms of post-acute infection syndromes (#PAIS). (1/)
dx.plos.org/10.1371/journa…
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A team member working on our #PrimeandSpike nasal spray COVID booster vaccine developed #longCOVID 😭
Long COVID is a global crisis affecting millions of lives. It is impacting our ability to do science, research and development.
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Grateful for the opportunity to coauthor this review with the incredible @michelle_monje 🙏🏼 We discuss pathobiology of #longCOVID in the central nervous system and speculate on chief mechanisms that contribute to this emerging neurological health crisis.
cell.com/neuron/fulltex…
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Nasal booster with recombinant spike protein or spike mRNA in PACE converts systemic immunity induced by primary vaccines into mucosal immunity
⬇️ Infection
⬇️ Transmission
🚫 Disease
Prime and Spike is published today 👇🏽
@tianyangmao @BenIsraelow
science.org/doi/10.1126/sc…
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An important study by @zalaly and colleagues of >13 million people shows that vaccines (prior to infection) only reduce #longCOVID risk by 15% with the largest risk reduction in blood clots and pulmonary sequelae but less protection of other organ systems. Please wear a mask! twitter.com/zalaly/status/…
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After many months of planning and hard work by so many (incl. @hmkyale @dianaberrent @wade_schulz @CharleszYaleMed @aaronmring @DaisySMassey @JeffGehlhausen), today, we are launching our research study to understand how vaccination may help improve #longcovid. 🧵 (1/n)
Pls RT🙏🏼
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Our study showing that Omicron subvariants are even more capable than other VOCs in suppressing MHC I expression to evade CD8 T cell immunity is just published. Congratulations to @MiyuMoriyama @carolilucas @ValterVSM @NathanGrubaugh & team 👏🏼 👏🏼 👏🏼 (1/)
pnas.org/doi/10.1073/pn…
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The latest summary of “How Long Covid Exhausts the Body” by @joshkellerjosh. Visual journalism at its best 👀
Happy to contribute insights with @nathavindra. Ft. @PutrinoLab @michelle_monje @microbeminded2 @Survivor_Corps @itsbodypolitic & patients.
nytimes.com/interactive/20…
We study innate and adaptive immunity against viruses and study disease pathogenesis. #COVID19 #longCOVID #vaccines @HHMINEWS @YaleIBIO @YaleMed @YaleCII