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Long COVID participants also had reduced central memory T cells and increased exhausted CD4 and CD8 T cells. The exhausted T cells suggest chronic antigens stimulating these T cells. What they are we do not know yet. (8/)
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Long COVID participants reported a number of symptoms, most commonly fatigue, brain fog, dysautonomia..etc. Hierarchical clustering of binary symptom data identified 3 clusters of patients with similar sets of self-reported symptoms. (6/)
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Long COVID group reported significant increases in the intensity of symptoms and dramatically worsened quality of life. Survey outcomes put together into a single classification metric “Long COVID Propensity Score or LCPS” demonstrated significant diagnostic potential. (5/)
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This is a cross-sectional multi-dimensional immune phenotyping & patient surveys in people with or without LC, who got COVID during the 2020 first wave, on average more than a year from infection. Most were not-hospitalized, ♀ dominant, younger to middle age. (4/)
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There are multiple hypotheses behind long COVID pathogenesis including persistent virus/viral remnants, autoimmunity, dysbiosis, virome reactivation and tissue damage. Our data will dive deep into some of these. (3/)
science.org/doi/10.1126/sc…
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Very excited to share our latest research on immunological features of #LongCovid. Our 2+ year collaboration with @PutrinoLab with many other fantastic colleagues and patients - Mount Sinai Yale Long COVID (MY-LC) study by @sneakyvirus1 et al. 🧵(1/)
medrxiv.org/content/10.110…
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I am honored to be included in this video to discuss #longCOVID. So grateful to the patients including @pamelarbishop @EfCovid19 @loscharlos for speaking up and teaching us what living with COVID is like. Please watch this today. @KnowableMag
youtube.com/watch?v=7lfGu_…
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I’m in the White House to participate in this summit on the future of COVID vaccines 🤩
So excited to discuss #primeandspike nasal booster vaccine!! twitter.com/WHCOVIDRespons…
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Sincere thank you to many of you who reached out to @POTUS and @WHCOVIDResponse in support of our efforts on nasal booster vaccine 🙏🏼
I will be speaking at the White House Summit on Future of COVID-19 Vaccines on July 26.
RSVP to join via livestream: pitc.zoomgov.com/webinar/regist…
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I am thrilled to coauthor an editorial piece for @SciImmunology with @EricTopol highlighting the need for Operation Nasal Vaccine—Lightning ⚡️ speed to counter COVID-19. Nasal spray boosters can induce local immunity to ⬇️ infection & transmission.
science.org/doi/10.1126/sc…
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Here is a piece I wrote with Dr. Albert Ko on why we need booster doses to maintain our immune responses against SARS-CoV-2. Help educate your immune system by being up to date with your booster doses to prevent severe COVID. @YaleCII @YaleSPH @YaleMed
time.com/6198402/covid-…
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An excellent article by @patrickc highlighting the barriers for academics like myself to develop universal and nasal COVID vaccines. We need government to empower someone to intervene and lift the roadblocks. Funding alone is not enough. Please read & RT👇🏽
slowboring.com/p/we-could-hav…
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What an honor to be featured in the latest BBC Science in Action with @michelle_monje! We discuss our latest research on how mild respiratory COVID can cause multi-lineage neural dysregulation with @PeaseRoland. Many thanks to @AndrewLuckBaker 🙏🏼
bbc.co.uk/sounds/play/w3…
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To help the parents navigate the COVID vaccines now approved for younger children, I collaborated with Dr. Thomas Murray @YalePediatrics @yalepedsid @ynhhealth to create this table using @BioRender for primary COVID vaccine series for different age groups.
Please share! (1/)
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For those interested in sharing science on Twitter, I wrote a short step-by-step guide on how to construct an effective thread. My new World View article in @NatImmunol (photo by @DanRenzetti). Hope you find it useful! #Scicomm
rdcu.be/cP05X
nature.com/articles/s4159…
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Reflection: persistent viral RNA has been seen post-COVID and after other viral infections. Targeting and getting rid of such RNA may hold key to the treatment of #longCOVID and #MECFS patients who suffer from this pathogenesis. (End)
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Consequences of persistent viral RNA may include organ-specific as well as nonspecific postviral syndromes such as long COVID, post-Ebola, and post-polio syndromes, characterized by symptoms including fatigue, headache, muscle pain, and joint pain. (3/)
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First question addressed is WHERE viral RNA can persist. After a variety of RNA virus infection, viral RNA can persist not only in immune privileged sites (brain, eyes, and testes), but also in blood, lymphoid tissue, joints, respiratory tract, GI tissues, and kidney. (2/)
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A brilliant & timely review by Prof. #DianeEGriffin on the persistence of viral RNA following RNA virus infection - which can be associated with late progressive disease or nonspecific lingering symptoms of post-acute infection syndromes (#PAIS). (1/)
dx.plos.org/10.1371/journa…
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@mocoband @fitterhappierAJ @DrEricDing @EricTopol @DrPatSoonShiong @farid__jalali @dgurdasani1 @jeremyfaust @ToshiAkima @RadCentrism @LeonardiBot @EnemyInAState Thank you @mocoband for sharing. This report adds to a growing evidence of viral persistence in the GI tract, possibly aided by virus shutting down MHC I and evading T cell killing.
biorxiv.org/content/10.110…
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An important study by @zalaly and colleagues of >13 million people shows that vaccines (prior to infection) only reduce #longCOVID risk by 15% with the largest risk reduction in blood clots and pulmonary sequelae but less protection of other organ systems. Please wear a mask! twitter.com/zalaly/status/…
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What could be the possible causes of PAIS? Similar to #longCOVID, we hypothesize a) pathogen reservoir/remnants, b) autoimmunity, c) dysbiosis of microbiome/virome, and d) unrepaired tissue damage. None are mutually exclusive. (6/)
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With millions of #longCOVID patients, it is becoming better known that even a mild infection can lead to longterm debilitating health problems. SARS-CoV-2 joins the long list of other pathogens that cause post-acute infection syndrome (PAIS). (2/)
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Please read our latest review by @jan_choutka et al. on “Unexplained post-acute infection syndromes”.
What a privilege to work with Jan Choutka, who is an #MECFS patient, expert and advocate. Grateful to @mhornig on her expertise/insights 🙏🏼 (1/)
nature.com/articles/s4159…
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It’s time to invest in next generation COVID vaccines that not only prevent severe disease but also block infection and transmission. It makes sense to induce mucosal immunity to fight a mucosal viral infection. My opinion in @nytimes today👇🏽
nytimes.com/2022/05/16/opi…
We study innate and adaptive immunity against viruses and study disease pathogenesis. #COVID19 #longCOVID #vaccines @HHMINEWS @YaleIBIO @YaleMed @YaleCII