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Finally @rahuldhodapkar used machine learning and found that immune features alone can predict long COVID with efficient discriminative performance (AUC=0.96)! The most informative individual data blocks contributing to efficient separation of groups are flow and cytokine. (21/)
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Several features significantly distinguished Long COVID (double negative B cells, serum galectin-1, various EBV epitopes) while others were negatively associated (serum cortisol, PD-1+ CD4+ TCM, and HSV1 and HSV2 motifs). (22/)
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In fact, serum cortisol was the most significant individual predictor of Long COVID status in the model, and alone was a predictor wit an AUC of 0.96 (95% CI: 0.92-0.99). Notably, serum cortisol within the MY-LC study was highest in HC > CC > LC. (23/)
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While we are so excited about the findings of this study, we also wish to highlight key limitations of this study. They are summarized here but there may be more. Our study is exploratory in nature and requires validation. (25/)
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Here is the summary of our findings. There are many implications for diagnosis and therapy for #longCOVID. (26/)
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For example, can we target viral reservoir with antivirals and mAbs? Can we restore cortisol levels? Should therapy be targeting EBV? Would immunomodulatory therapy against inflammatory cytokines be useful? We still need to identify long COVID endotypes for treatment. (27/)
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We hope that our study will be informative to others working in the field. We need validation across cohorts. We also hope that these data will help those who are still skeptical understand that long COVID is real, and it has biological basis. Thank you for reading. (End)
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I could not agree more with @EricTopol 👇🏽
While we are gaining more insights into the disease pathogenesis of #longCOVID, we also need to start well-designed randomized clinical trials now! Patients cannot wait any longer, and scientists will learn from RCTs to improve therapy. twitter.com/EricTopol/stat…
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Very happy to see that China approved the world’s first inhaled vaccine against COVID-19. Convidecia Air is an aerosolized vaccine based on Ad5-nCoV made by Cansino.
fortune.com/2022/09/05/can…
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新型コロナ後遺症に関する私たちの研究についてお話しを記事にしていただきました。メカニズムの解析は進んでいますが、さらなる研究と臨床試験が必要です。世界中で苦しんでいる多くの人に役立つ治療に貢献したいです。是非日経サイエンスの特集を読んで下さい👇🏽 #longCOVID
nikkei-science.com/202211_039.html
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Grateful for the opportunity to coauthor this review with the incredible @michelle_monje 🙏🏼 We discuss pathobiology of #longCOVID in the central nervous system and speculate on chief mechanisms that contribute to this emerging neurological health crisis.
cell.com/neuron/fulltex…
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For those who are interested in learning more about how COVID and #longCOVID can impact the brain, I highly recommend this video interview by @KnowableMag of @michelle_monje 👇🏽
knowablemagazine.org/article/health…
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A more general discussion and powerful testimony by #longCOVID patients can be found in this video by @KnowableMag. I share hypotheses on disease pathogenesis and discuss possible therapies. Please listen to the patients and learn more.
knowablemagazine.org/article/health…
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Nasal booster with recombinant spike protein or spike mRNA in PACE converts systemic immunity induced by primary vaccines into mucosal immunity
⬇️ Infection
⬇️ Transmission
🚫 Disease
Prime and Spike is published today 👇🏽
@tianyangmao @BenIsraelow
science.org/doi/10.1126/sc…
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Very excited to receive the book THE LONG COVID SURVIVAL GUIDE edited by @fi_lowenstein. This book has many great insights and ‘how-to’ tips from amazing patient experts and researchers, including @PutrinoLab. Honored to contribute an afterword 🙏🏼 #MustRead #longcovid
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So grateful to receive the 2022 Johadamis ME/CFS Research Grant! In collaboration with @polybioRF @BjornBragee we will test blood & CSF samples from #MECFS patients for immune phenotypes and antibodies to various pathogens. This will inform us about potential drivers of disease. twitter.com/Tempi_Stiftung…
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Is there anything we can do to prevent long COVID, once we catch the virus? Research by @zalaly and colleagues shows that Paxlovid treatment within 5 days of a positive test led to 26% less risk of #longCOVID, regardless of vaccine status. (1/2)
medrxiv.org/content/10.110…
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Delighted to host @resiapretorius and @PutrinoLab at Yale today. @ValterVSM and I learned how to image #microclots and activated platelets. Activated platelet stained with anti-CD62P antibody are evident just looking through the eyepiece 👀 This is from a #longCOVID patient👇🏽😭
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Getting ready for this town hall meeting👩🏻💻 I will discuss the latest results from MY-LC study with @PutrinoLab and also provide my updated hypotheses on the pathogenesis of long COVID and vaccine-related long-haul diseases based on data from the Yale LISTEN study with @hmkyale. twitter.com/kindred_health…
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@cstroeckw Many thanks to you and other patient advocates, this pandemic has propelled me to investigate the pathobiology of #longCOVID, #MECFS and #longLyme 🙏🏼 If enough people do the same, we can change how society and medicine view post-acute infection syndromes.
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Lack of funding for the next generation COVID vaccines, including nasal spray boosters, will slow our progress in providing immunity where it’s needed - at the point of viral entry👃🏼
Thank you @VinGuptaMD @NBCNews for this news coverage!
#mucosalvaccine
youtu.be/aIaeRaNyFX0
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A while ago, @MiyuMoriyama et al showed that SARS-CoV-2 variants suppress MHC I levels in infected cells to the same degree as the ancestral virus. Then came the Omicron variants. A short update. (1/) biorxiv.org/content/10.110… twitter.com/VirusesImmunit…
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New data are pretty striking. Compared to the ancestral (WA1) or Epsilon (B.1.429) variant, Omicron subvariants BA.1, BA.2.12.1, XAF and BA.4 all suppressed MHC I surface expression better in infected cells. An irrelevant surface marker (CD324) was not affected by infection. (4/)
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Our new data demonstrate the evolution of the Omicron variants in further suppressing MHC I expression and escaping detection/killing by CD8 T cells. Thus, in addition to evasion from Ab and innate immunity, MHC I ⬇️ by Omicron may further ⬆️ replication & transmission. (End)
We study innate and adaptive immunity against viruses and study disease pathogenesis. #COVID19 #longCOVID #vaccines @HHMINEWS @YaleIBIO @YaleMed @YaleCII