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CD8 T cells help fight off viral infection by detecting and killing infected cells. CD8 T cells detect MHC I + viral peptide on infected cells. One of the common tricks viruses use to avoid killing is to inhibit MHC I expression and presentation. (2/)
pubmed.ncbi.nlm.nih.gov/19498380/
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Every school bus in the country should be adhering to these guidelines to avoid COVID transmission.
✅ Universal masking
✅ SalivaDirect testing
✅ <2 students/seat with the exception of 3/seat with siblings
✅ a one-inch window opening in the 2 middle and 2 last row windows twitter.com/linseymarr/sta…
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An excellent piece on why we should be looking to nasal spray as the future of COVID booster vaccines by @Carolynyjohnson
@NIAIDNews please include our Prime and Spike in the upcoming vaccine bake-off 🥺
washingtonpost.com/health/2022/04…
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My lab is looking for a project manager. If you are interested in a research associate position to oversee biorepository and manage cool #longCOVID immune profiling and #neuroimmune mouse projects, please apply below 👇🏽
sjobs.brassring.com/TGnewUI/Search…
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Getting ready for this town hall meeting👩🏻💻 I will discuss the latest results from MY-LC study with @PutrinoLab and also provide my updated hypotheses on the pathogenesis of long COVID and vaccine-related long-haul diseases based on data from the Yale LISTEN study with @hmkyale. twitter.com/kindred_health…
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In CoronaVac fully vaccinated (2x) people, there was NO detectable neutralization against the infectious Omicron virus. Antibodies were assayed at mean days from second Coronavac shot of 113 days (with SD 33 days). (5/)
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What could be the possible causes of PAIS? Similar to #longCOVID, we hypothesize a) pathogen reservoir/remnants, b) autoimmunity, c) dysbiosis of microbiome/virome, and d) unrepaired tissue damage. None are mutually exclusive. (6/)
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Previously infected people had higher neutralization against variants than the uninfected in response to vaccination. Future vaccine boosters may help to overcome such NAb reduction observed for the variants with the L452R (B.1.617.2) or E484K & N501Y combo (P.1 , B.1.351). (15/)
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An important study from @blish_lab and Tracey McLaughlin groups showing that mature adipocytes and adipose tissue macrophages become infected with SARS-CoV-2. Another potential viral reservoir?
By @RoniNYTimes with comments from @VishwaDeepDixi1
biorxiv.org/content/10.110… twitter.com/NYTScience/sta…
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This new preprint by Stadler et al. integrated data from 37 randomized controlled trials to ask how the timing and dose of passive antibodies (monoclonal Ab & convalescent plasma) predict protection from SARS-CoV-2 disease. A short 🧵 (1/)
medrxiv.org/content/10.110…
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@bucketwoman0 @DocMoschos @kallmemeg Yes. Fully vaccinated people can still get long covid. Please see this entire thread by @dianaberrent 👇🏽 twitter.com/dianaberrent/s…
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Unfortunately, in the CoronaVac 2x recipients boosted with Pfizer mRNA vax, prior infection made no difference to the neutralization capacity against Omicron. (8/)
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Overall, this study adds to growing evidence that vaccines can improve symptoms and lessen the disease impact in #longCOVID.
What is the evidence? An important patient survey from @LongCovidSOS showed impact of vaccines on long covid symptoms. (5/)
…e-4609-b25f-6f3d1497c4cf.filesusr.com/ugd/8bd4fe_a33…
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A very informative thread by @angie_rasmussen on how the delta variant may be more contagious. Striking findings 👇🏽
virological.org/t/viral-infect… twitter.com/angie_rasmusse…
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A new study by @carolilucas lab shows that vaccine booster type matters, especially for 50 and older. After the CoronaVac primary series, BNT162b2 or ChAdOx1 booster produces better neutralizing antibodies than the CoronaVac booster. @ScienceTM
science.org/doi/10.1126/sc…
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📣 New prize for young scientists (<35 years of age) working on transformative research in human immunology, with a first prize of $30,000 and runner-up prizes of $10,000.
Michelson Philanthropies & Science Prize for Immunology
Apply here 👇🏽
sciencemag.org/prizes/michels…
We study innate and adaptive immunity against viruses and study disease pathogenesis. #COVID19 #longCOVID #vaccines @HHMINEWS @YaleIBIO @YaleMed @YaleCII