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Today, we enrolled our 100th long covid patients in our collaboration with the @PutrinoLab to understand the pathogenesis of #longCOVID. So grateful to David, his team members and the patients for donating their blood samples 🙏🏼
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How does COVID reinfection happen?
Our deep dive into the immune profiles during the 1st and 2nd infections. A case study.
Work led by @sneakyvirus1 @AndersonBrito_ Paul Turbin @peowenlu @BenIsraelow and Marwan Azar (1/)
medrxiv.org/content/10.110…
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For those interested in sharing science on Twitter, I wrote a short step-by-step guide on how to construct an effective thread. My new World View article in @NatImmunol (photo by @DanRenzetti). Hope you find it useful! #Scicomm
rdcu.be/cP05X
nature.com/articles/s4159…
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I am honored to be included in this video to discuss #longCOVID. So grateful to the patients including @pamelarbishop @EfCovid19 @loscharlos for speaking up and teaching us what living with COVID is like. Please watch this today. @KnowableMag
youtube.com/watch?v=7lfGu_…
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We need your help for some crucial #LongCOVID research! If you live in the New York area, have FULLY recovered from COVID-19 infection and it has been AT LEAST 12 weeks since you were first sick, please email us at prcovid@mountsinai.org @PutrinoLab
RT highly appreciated 🙏🏼
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How do the various mutations within the SARS-CoV-2 variants impact vaccine-induced immunity? The amazing @carolilucas @VogelsChantal @InciYildirim11 led this study with with help from others to tackle this question - using 18 CoV-2 variants. (1/n)
medrxiv.org/content/10.110…
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@cstroeckw Many thanks to you and other patient advocates, this pandemic has propelled me to investigate the pathobiology of #longCOVID, #MECFS and #longLyme 🙏🏼 If enough people do the same, we can change how society and medicine view post-acute infection syndromes.
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I highly recommend this very informative thread posted by @michelle_monje on this study. twitter.com/michelle_monje…
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So excited to launch the new Center for Infection & Immunity @YaleCII at @YaleMed!! This center will investigate fundamental mechanisms of infection and immunity that hold key to better prevention, diagnosis and treatment of wide range of diseases. (1/)
medicine.yale.edu/cii/
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A new study by @YaleSPH @ChenKai_yale & team shows that SARS-CoV-2’s reproductive number is attributable to seasonal factors; temperature (3.73%), humidity (9.35%) and UV radiation (4.44%).
We need to vaccinate before the cold, dry, dark winter hits.
news.yale.edu/2021/06/14/hea…
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Thankfully, we have not seen any evidence of antibody-dependent enhancement of infection or disease by any COVID vaccines to date. Vaccine are not making infections worse, and are very effective in preventing disease. twitter.com/VirusesImmunit…
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For those who are interested in learning more about how COVID and #longCOVID can impact the brain, I highly recommend this video interview by @KnowableMag of @michelle_monje 👇🏽
knowablemagazine.org/article/health…
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I could not agree more with @EricTopol 👇🏽
While we are gaining more insights into the disease pathogenesis of #longCOVID, we also need to start well-designed randomized clinical trials now! Patients cannot wait any longer, and scientists will learn from RCTs to improve therapy. twitter.com/EricTopol/stat…
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The dark side of #scicomm is that being out there giving interviews comes at a significant cost. I still do this because it is important to provide facts that are helpful to people, and to combat mis/disinformation that are harmful to people. But the abuse has got to stop 🛑 twitter.com/Nature/status/…
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There are multiple hypotheses behind long COVID pathogenesis including persistent virus/viral remnants, autoimmunity, dysbiosis, virome reactivation and tissue damage. Our data will dive deep into some of these. (3/)
science.org/doi/10.1126/sc…
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Here is my interview on “What's causing long COVID?” with @NakedScientists
Viral reservoir
Autoimmunity
Vaccine and #LongCovid
thenakedscientists.com/articles/inter…
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Very excited that our PaxLC clinical trial on #longCOVID patients is now open, led by @hmkyale! This is a phase 2, 1:1 randomized, double-blind, placebo-controlled research study in 100 non-hospitalized highly symptomatic long COVID. (1/)
clinicaltrials.gov/ct2/show/NCT05…
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Sincere thank you to many of you who reached out to @POTUS and @WHCOVIDResponse in support of our efforts on nasal booster vaccine 🙏🏼
I will be speaking at the White House Summit on Future of COVID-19 Vaccines on July 26.
RSVP to join via livestream: pitc.zoomgov.com/webinar/regist…
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An important new study looks at how COVID vaccines impacts symptoms in #LongCovid patients. @thitran3’s team used data from ComPaRe long COVID cohort to emulate a target trial (1:1 matched vax:unvax) measuring outcome at 120 days after baseline. (1/)
papers.ssrn.com/sol3/papers.cf…
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Next, with @nathavindra, autopsies from 9 individuals found to be SARS-CoV-2-positive by nasal swab PCR at the time of death were examined. Brains from those with even mild or asymptomatic SARS-CoV-2 infection had microglial reactivity in subcortical white matter. (8/)
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Reflection: persistent viral RNA has been seen post-COVID and after other viral infections. Targeting and getting rid of such RNA may hold key to the treatment of #longCOVID and #MECFS patients who suffer from this pathogenesis. (End)
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Has anyone else with #longCOVID received monoclonal antibodies to SARS-CoV-2? Please share your experience. More data will help justify a clinical trial. Thank you. twitter.com/AlisaValdesRod…
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It’s finally happening! I will be giving a talk today at the #AAI2021 with Dr. Fauci and Dr. Saif in the session, COVID-19 and the Science of Pandemics (12-2PM ET).
My talk will be on “Protective vs. harmful immune responses in COVID-19”. See you there!
immunology2021.org/scientific-pro…
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Please read our latest review by @jan_choutka et al. on “Unexplained post-acute infection syndromes”.
What a privilege to work with Jan Choutka, who is an #MECFS patient, expert and advocate. Grateful to @mhornig on her expertise/insights 🙏🏼 (1/)
nature.com/articles/s4159…
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In fact, serum cortisol was the most significant individual predictor of Long COVID status in the model, and alone was a predictor wit an AUC of 0.96 (95% CI: 0.92-0.99). Notably, serum cortisol within the MY-LC study was highest in HC > CC > LC. (23/)
We study innate and adaptive immunity against viruses and study disease pathogenesis. #COVID19 #longCOVID #vaccines @HHMINEWS @YaleIBIO @YaleMed @YaleCII