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I’m so grateful that @japanairlinesJP requires masking in the airplane and at airports 🙏🏼
Taking off to Tokyo to celebrate the winners of the Maria Sklodowska-Curie Prize for young female scientists 👩🏻🔬
27
Excited to share our work by @BenIsraelow et al published today. We asked what are the roles of antibodies vs. T cells in controlling primary infection, reinfection, and vaccine-mediated protection? (1/n)
science.org/doi/10.1126/sc…
28
@sciliz I’m concerned because of the putative ability of XBB.1.5 to have increased capacity to infect cell types that express even lower levels of ACE2. This will increase tropism and possibly persistence in cell types that are long lived.
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We hope that our study will be informative to others working in the field. We need validation across cohorts. We also hope that these data will help those who are still skeptical understand that long COVID is real, and it has biological basis. Thank you for reading. (End)
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This thread is about alpha-gal syndrome (AGS) - meat allergy induced by tick bites. I’ve been living with AGS for >2 yrs. I hope this info will help those who suffer from this illness without knowing the cause. Please help bring awareness to #AGS (1/n)
resident360.nejm.org/clinical-pearl…
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In terms of public health, CoronaVac 2x is insufficient to neutralize Omicron. Even with CoronaVac 2x plus Pfizer booster, NAb is only 1.4x higher than 2x mRNA alone. Thus, CoronaVac recipients may need 2 additional booster doses to reach levels needed against Omicron. (10/)
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An important study by @zalaly and colleagues of >13 million people shows that vaccines (prior to infection) only reduce #longCOVID risk by 15% with the largest risk reduction in blood clots and pulmonary sequelae but less protection of other organ systems. Please wear a mask! twitter.com/zalaly/status/…
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This study also opens up all kinds of questions and possibilities. For example, therapies that can 1) block inflammatory cytokines, 2) block inducers of such cytokines, or 3) reset reactive microglia can be considered for future clinical trials. Thank you for reading till end.
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The latest summary of “How Long Covid Exhausts the Body” by @joshkellerjosh. Visual journalism at its best 👀
Happy to contribute insights with @nathavindra. Ft. @PutrinoLab @michelle_monje @microbeminded2 @Survivor_Corps @itsbodypolitic & patients.
nytimes.com/interactive/20…
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What an incredible honor to be invited to have lunch at the @WhiteHouse by Dr. Jill Biden in honor of Mrs. Yuko Kishida, spouse of the Prime Minister of Japan. I discussed #LongCovid, nasal vaccines, and the importance of science with powerful women 🌸
asahi.com/ajw/articles/1…
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The #LongCovidAwarenessDay (today) is important because in many countries and regions around the world, long COVID is not discussed and people are suffering in isolation. Awareness is needed to improve diagnosis, medical care, research, and support of patients 💙
38
In this study, @MiyuMoriyama et al investigate how well SARS-CoV-2 variants of concern (VOC) suppress MHC I needed for recognition by cytotoxic T cells. This question is important to understand how well the virus limits CD8 killing 🧵(1/) @biorxivpreprint
biorxiv.org/content/10.110…
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I am thrilled to coauthor an editorial piece for @SciImmunology with @EricTopol highlighting the need for Operation Nasal Vaccine—Lightning ⚡️ speed to counter COVID-19. Nasal spray boosters can induce local immunity to ⬇️ infection & transmission.
science.org/doi/10.1126/sc…
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After many months of planning and hard work by so many (incl. @hmkyale @dianaberrent @wade_schulz @CharleszYaleMed @aaronmring @DaisySMassey @JeffGehlhausen), today, we are launching our research study to understand how vaccination may help improve #longcovid. 🧵 (1/n)
Pls RT🙏🏼
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Our new study by @JieunOh9 @ericsongg @MiyuMoriyama et al shows that immune priming via intranasal route provides superior protection against heterologous respiratory virus challenge. The key is in inducing local secretory IgA with broader coverage. (1/)
science.org/doi/10.1126/sc…
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Long COVID participants also had reduced central memory T cells and increased exhausted CD4 and CD8 T cells. The exhausted T cells suggest chronic antigens stimulating these T cells. What they are we do not know yet. (8/)
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In our study published today, we show;
1) mRNA vaccines (2 shots) induce robust antibodies & T cells to SARS-CoV-2
2) certain mutations in VOC ⬆️ Ab escape
3) prior infection + 2 mRNA shots produce very high neutralizing Ab against most VOC 🦠(1/)
nature.com/articles/s4158…
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Thrilled to share this Comment in @TheLancetInfDis that I coauthored with the amazing @PutrinoLab on “Why we need a deeper understanding of the pathophysiology of long COVID”. Sharing an accessible document here. Thank you for reading and sharing 🙏🏼
thelancet.com/journals/lanin…
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For example, can we target viral reservoir with antivirals and mAbs? Can we restore cortisol levels? Should therapy be targeting EBV? Would immunomodulatory therapy against inflammatory cytokines be useful? We still need to identify long COVID endotypes for treatment. (27/)
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“Long COVID has not received anywhere near the same level of attention or resources: the result has been widespread harm to health, societies, and economies. 3 years in, more is needed to recognise, treat, and support patients with long COVID.” 💯
thelancet.com/journals/lance…
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Omg 🤩
Our Prime and Spike 👃🏼 vaccine story is in the @RollingStone 👩🏻🔬
By @daxe with comments from @BenIsraelow
rollingstone.com/culture/cultur…
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A while ago, @MiyuMoriyama et al showed that SARS-CoV-2 variants suppress MHC I levels in infected cells to the same degree as the ancestral virus. Then came the Omicron variants. A short update. (1/) biorxiv.org/content/10.110… twitter.com/VirusesImmunit…
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Very excited to receive the book THE LONG COVID SURVIVAL GUIDE edited by @fi_lowenstein. This book has many great insights and ‘how-to’ tips from amazing patient experts and researchers, including @PutrinoLab. Honored to contribute an afterword 🙏🏼 #MustRead #longcovid
We study innate and adaptive immunity against viruses and study disease pathogenesis. #COVID19 #longCOVID #vaccines @HHMINEWS @YaleIBIO @YaleMed @YaleCII